All Publications

2024

Amy Elizabeth Hutton,   Jake Foster,   James E. J. Sanders,   Christopher J Taylor,   Stefan A Hoffmann,  Yizhi Cai,   Sarah L. Lovelock  and  Anthony P. Green*, An Efficient Pyrrolysyl-tRNA Synthetase for Economical Production of MeHis-containing Enzyme. Faraday Discuss., Accepted Manuscript (2024). Read here.

Amy E. Hutton, Jake Foster, Rebecca Crawshaw, Florence J. Hardy, Linus O. Johannissen, Thomas M. Lister, Emilie F. Gérard, Zachary Birch-Price, Richard Obexer, Sam Hay, Anthony P. Green*, A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme. Nature Communications volume 15, Article number: 1956 (2024), Read here.

2023

Jingming Zhao, Ying Zhuo, Daniel E. Diaz, Muralidharan Shanmugam, Abbey J. Telfer, Peter J. Lindley, Daniel Kracher, Takahiro Hayashi, Lisa S. Seibt, Florence J. Hardy, Oliver Manners, Tobias M. Hedison, Katherine A. Hollywood, Reynard Spiess, Kathleen M. Cain, Sofia Diaz-Moreno, Nigel S. Scrutton, Morten Tovborg, Paul H. Walton*, Derren J. Heyes*, Anthony P. Green*, Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase. J. Am. Chem. Soc., 2023, 145, 37, 20672–20682, Read here

Zachary Birch-Price, Christopher J. Taylor, Mary Ortmayer, Anthony P. Green, Engineering Enzyme Activity Using an Expanded Amino Acid Alphabet. Protein Engineering, Design and Selection, 2023, 36, gzac013, Read here

2022

Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J.B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green, A Designed Photoenzyme for Enantioselective [2+2]-Cycloadditions. Nature, 2022, 611, 709-714 Read here

Elizabeth Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, S. Ramachandran, A. Tedstone, S. Haigh, A. Garforth, P. Day, Colin Levy, Michael Shaver, and Anthony P. Green, Directed Evolution of an Efficient and Thermostable PET Depolymerase. Nature Catalysis, 2022, 5, 673-681 Read here

Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker, Donald Hilvert, Anthony P. Green, The Road to Fully Programmable Protein Catalysis. Nature, 2022, 606, 49-58 Read here

A. J. Burke, W. R. Birmingham, Y. Zhuo, T. W. Thorpe, B. Zucoloto da Costa, R. Crawshaw, I. Rowles, J. D. Finnigan, C. Young, G. M. Holgate, M. P. Muldowney, S. J. Charnock, S. L. Lovelock, N. J. Turner, A. P. Green, An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir. J. Am. Chem. Soc., 2022, 144, 3761-3765. Read here Nature Research Highlight, ACS Editor’s choice, associated article in New Statesman, a prominent British political and cultural magazine ‘Democratising Medicine: Creating Fair Access to Medicines’ (in press)

2021

R. Crawshaw, A. E. Crossley, L. Johannissen, A. J. Burke, S. Hay, C. Levy, D. Baker, S. L. Lovelock & A. P. Green, Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction. Nature Chemistry 2022, 14, 313-320 Read here. Highlighted in Chemistry World. Nature Catalysis research highlight. Nature Chemistry News & Views.

M. Ortmayer, F. J. Hardy, M. G. Quesne, K. Fisher, C. Levy, D. J. Heyes, C. R. A. Catlow, S. P. de Visser, S. E. J. Rigby, S. Hay, A. P. Green, A non-canonical tryptophan analogue reveals an active site hydrogen bond controlling ferryl reactivity in a heme peroxidase. JACS Au 2021 (Accepted/In Press) Read here

2020

F. J. Hardy, M. Ortmayer, A. P. Green, C. E. M. Noble, J. L. R. Anderson, Recent Advances in Understanding, Enhancing and Creating Heme Peroxidases, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2020. Read here

M. Ortmayer, K. Fisher, J. Basran, E. M. Wolde-Michael, D. J. Heyes, C. Levy, S. L. Lovelock, J. L. R. Anderson, E. L. Raven, S. Hay, S. E. J. Rigby, A. P. Green, Rewiring the ‘push-pull’ catalytic machinery of a haem enzyme using an expanded genetic code. ACS Catalysis, 2020, 10, 2735. Read here

J. Zhao, A. J. Burke, A. P. Green, Enzymes with Non-Canonical Amino Acids. Curr. Opin. Chem. Biol. 2020, 55, 136. Read here

G. Paggiola, N. Derrien, J. D. Moseley, A. P. Green, S. Flitsch, J. H. Clark, C. R. McElroy, A. J. Hunt, Application of bio-based solvents for biocatalysed synthesis of amides with Pseudomonas stutzeri lipase (PSL). Pure Appl. Chem, 2020, 92 (4), 579-586. Read here

2019

A. J. Burke, S. L. Lovelock, A. Frese, R. Crawshaw, M. Ortmayer, M. Dunstan, C. Levy, A. P. Green, Design and Evolution of an Enzyme with a Non-Canonical Organocatalytic Mechanism. Nature 2019, 570, 219.  Read here Highlighted in C&E News.

A. Debon, M. Pott, R. Obexer, A. P. Green, L. Friedrich, A. Griffiths, D. Hilvert, Ultrahigh-Throughput Screening Enables Efficient Single-Round Oxidase Remodeling. Nature Catalysis, 2019, 2, 740. Read here

2018

J. Xu, A. P. Green, N. J. Turner, Chemoenzymatic Synthesis of Pyrazines and Pyrroles. Angew. Chem. Int. Ed. 2018, 57, 16760. Read here

T. Hayashi, D. Hilvert, A. P. Green, Engineered Metalloenzymes with Non-Canonical Coordination Environments. Chem. Eur. J. 2018, 24, 11821. Read here

M. Pott, T. Hayashi, T. Mori, P. R. E. Mittl, A. P. Green, D. Hilvert, A Non-Canonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold. J. Am. Chem. Soc. 2018, 140, 1535. Read here

2017

C. J. Gray, B. Schindler, L. G. Migas, M. Pičmanová, A. R. Allouche, A. P. Green, S. Mandal, M. S. Motawia, R. Sánchez-Pérez, N. Bjarnholt, B. L. Møller, A. M. Rijs, P. E. Barran, I. Compagnon, C. E. Eyers, S. L. Flitsch, Bottom-Up Elucidation of Glycosidic Bond Stereochemistry. Anal. Chem. 2017, 89, 4540 Read here

A. P. Green, S. Hardy, E. J. Thomas, Synthetic Approaches to the C11–C27 Fragments of Bryostatins. Org. Biomol. Chem. 2017 15, 9475 Read here

A. P. Green, S. Hardy, A. T.L. Lee, E. J. Thomas, Total Synthesis of 7-des-O-Pivaloyl-7-O-Benzylbryostatin 10. Org. Biomol. Chem. 2017, 15, 9497-9526 Read here

A. P. Green, E. O’Reilly, 2017, Ortho-Xylylenediamine Dihydrochloride. In Encyclopedia of Reagents for Organic Synthesis. Read here

2016

A. P. Green, N. J. Turner, Biocatalytic Retrosynthesis: Redesigning Synthetic Routes to High-Value Chemicals, Perspectives in Science 2016, 9, 42-48 Read here

A. P. Green, T. Hayashi, P. R. E. Mittl, D. Hilvert, A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme. J. Am. Chem. Soc. 2016, 138, 11344. Read here JACS Editor’s choice, Highlighted in ACS Chemical Biology

A. Gomm, W. Lewis, A. P. Green, E. O’Reilly, A New Generation of Smart Amine Donors for Transaminase-Mediated Biotransformations. Chem. Eur. J. 2016, 22, 12692 Read here

Anthony Green - Mentored Publications

A. P. Green, N. J. Turner, E. O’Reilly, Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor Which Displaces Equilibria and Enables High-Throughput Screening. Angew. Chem. Int. Ed. 2014, 53, 10714. VIP article, Highlighted in C&E News 2014, vol. 92, Issue 35, p. 13., Highlighted in Nature Chemistry 2014, 6, 849, Highlighted in synfacts and selected for F1000Prime

A. P. Green, N. J. Turner, E. O’Reilly, Enzymatic Processes and Uses. Publication number WO2016009195 A1

J. W. Schmidberger, L. J. Hepworth, A. P. Green, S. L. Flitsch, Enzymatic Synthesis of Amides. Science of Synthesis, Biocatalysis in Organic Synthesis Volume 1, 329.

P. Both, A. P. Green, C. J. Gray, R. Šardzík, J. Voglmeir, C. Fontana, M. Austeri, M. Rejzek, D. Richardson, R. A. Field, G. Widmalm, S. L. Flitsch and C. E. Eyers, Discrimination of Epimeric Glycans and Glycopeptides using IM-MS and its Potential for Carbohydrate Sequencing. Nature Chem. 2014, 6, 65.

L. Heap, A. P. Green, D. Brown, B. van Dongen , N. J. Turner, Role of Laccase as an Enzymatic Pretreatment Method to Improve Lignocellulosic Saccharification. Catal. Sci. Technol. 2014, 4, 2251.

D. Ghislieri, A. P. Green, M. Pontini, S. C. Willies, I. Rowles, A. Frank, G. Grogan, N. J. Turner, Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products. J. Am. Chem. Soc. 2013, 135, 10863. Hot article, Highlighted in C&E News 2013, vol. 91, Issue 30, p. 34., JACS editor’s choice

D. Ghislieri, D. Houghton, A. P. Green, S. C. Willies, N. J. Turner, Monoamine Oxidase (MAO-N) Catalyzed Deracemization of Tetrahydro-β-carbolines: Substrate Dependent Switch in Enantioselectivity. ACS Catal. 2013, 3, 2869.

K. Adlington, A. P. Green, W. Wang, S. M. Howdle, D. J. Irvine, Direct ‘In Situ’, Low VOC, High Yielding, CO2 Expanded Phase Catalytic Chain Transfer Polymerisation: Towards Scale-up. Dalton Trans. 2013, 42, 127.

R. Šardzík, A. P. Green, N. Laurent, P. Both, C. Fontana, J. Voglmeir, M. J. Weissenborn, R. Haddoub, P. Grassi, S. M. Haslam, G. Widmalm, S. L. Flitsch, Chemoenzymatic Synthesis of O-Mannosylpeptides in Solution and on Solid Phase. J. Am. Chem. Soc. 2012, 134, 4521.

P. Both, R. Sardzik, M. Weissenborn, A. P. Green, J. Voglmeir, S. L. Flitsch, Glycoarrays on Gold Surfaces - Cracking the Sugar Code by Navigating the Glycospace Proceedings of the 2nd Beilstein Symposium on Glyco-Bioinformatics, 2012, 93.

A. P. Green, A. T. L. Lee, E. J. Thomas, Total Synthesis of a 20-Deoxybryostatin. Chem. Commun. 2011, 47, 7200. Hot article

A. P. Green, S. Hardy, A. T. L.  Lee, E. J. Thomas, Approaches to the Total Synthesis of Biologically Active Natural Products: Studies Directed Towards Bryostatins. Phytochem. Rev. 2010, 9, 501-513.

J. V. Allen, A. P. Green, S. Hardy, N. M. Heron, A. T. L. Lee, E. J. Thomas On the use of the Modified Julia Olefination for Bryostatin Synthesis. Tetrahedron Lett. 2008, 49, 6352-6355.

A. P. Green, S. Hardy. E. J. Thomas, A Synthesis of the C(17)-C(27) Fragment of Bryostatin 1. Synlett 2008, 14, 2103-2106.